Identification of Celastramycin as a Novel Therapeutic Agent for Pulmonary Arterial Hypertension-High-throughput Screening of 5,562 Compounds-

Ryo Kurosawa,Kimio Satoh,Nobuhiro Kikuchi,Haruhisa Kikuchi,Daisuke Saigusa,Md. Elias-Al-Mamun,Mohammad Abdul Hai Siddique,Junichi Omura,Taijyu Satoh,Shinichiro Sunamura,Masamichi Nogi,Kazuhiko Numano,Satoshi Miyata,Akira Uruno,Kuniyuki Kano,Yotaro Matsumoto,Takayuki Doi,Junken Aoki,Yoshiteru Oshima,Masayuki Yamamoto,Hiroaki Shimokawa

Identification of Celastramycin as a Novel Therapeutic Agent for Pulmonary Arterial Hypertension-High-throughput Screening of 5,562 Compounds-

2019

Rationale: Pulmonary arterial hypertension (PAH) is characterized by enhanced proliferation of pulmonary artery smooth muscle cells (PASMCs) accompanying increased production of inflammatory factor...

Keywords:

Biology
Cardiology
Internal medicine
Diabetes mellitus
Myocyte
Pulmonary artery
High-throughput screening
Reactive oxygen species
Hypoxia-Inducible Factor 1
energy metabolism
Cell growth
smooth muscle

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