Pathological prognostic factors in a series of 137 stage I TNM/UICC endometrial carcinomas.

Abstract Purpose : We report on the long-term results of combination surgery-radiotherapy in cT1 carcinoma of the endometrium according to prognostic factors. Patients and methods : From 1974 to 1993, 130 women suffering from cT1N x -O Mo endometrial carcinoma, underwent surgical resection. The median age was 62 years. Thirteen received pre-operative irradiation, two pre-operative brachytherapy followed by post-operative external irradiation and 115 patients (88.35%) underwent post-operative irradiation therapy by brachytherapy or external beam irradiation. Results : The median follow-up is 67 months. Overall and specific survival rates for patients with c T1pT1 tumours were 71.1 and 85% at 10 years. For overall survival, lymph node invasion was the most powerful prognostic factor in the multivariate analysis ( P =0.02). If lymph node invasion is not taken into account, the WHO histological grade exerts a significant prognostic impact ( P =0.001). Conclusion : For stage cT1 endometrial carcinoma, primary surgery allows radiotherapy to be adjusted according to the WHO histological grade, myometrial invasion and the pelvic lymph node status.