Tobacco, antioxidant enzymes, oxidative stress, and genetic susceptibility in oral cancer.

Objectives:Oral cancer accounts third of all malignancies in India. Tobacco use, the major etiological factor for oral cancer is known to generate free radicals resulting in alterations in antioxidant enzymes like, glutathione-S-transferase (GST), glutathione reductase, superoxide dismutase, catalas