Plasmodium falciparum liver-stage antigen-1 peptide-specific interferon-gamma responses are not suppressed during uncomplicated malaria in African children

INTRODUCTION The emergence of multi-drug resistant Plasmodium falciparum is a rapidly increasing problem world-wide [1], making the need for an effective vaccine more urgent than ever. One of the main prerequisites for the development of a successful vaccine is a good understanding of the naturally acquired immune responses directed against the parasite, and the lack of such knowledge is currently one of the many obstacles impeding research [...]