P80-T EEG-markers of the passive hand movement in patients after STBI with normal fMRI motor response

Background Severe traumatic brain injury (STBI) is almost always accompanied by movement disorders. The use of electroencephalography (EEG), supplemented by mathematical analysis, in combination with functional magnetic resonance imaging (fMRI) expands the possibilities of studying brain neuroplasticity as a basis for compensation post-traumatic motor disorders. Material and methods Multichannel EEG and fMRI 3T during passive motor test (hand finger clenching by experimenter) were performed in 28 patients with STBI and 17 healthy subjects. The most detailed spectral-coherent analysis of spatial EEG changes was performed in 10 patients with varying degrees of hemiparesis, but similar to the norm fMRI response. Results It was revealed that individual EEG restructurings in a passive motor test in patients with STBI are characterized by significant variability and the inclusion of the brain regions not typical for the norm. Secondary statistical analysis showed that the topography of EEG coherence changes shows the greatest correlation with the degree of hemiparesis: increased reactivity of the frontal-central areas in the ipsilateral hemisphere relative movement with mild hemiparesis and the inclusion of both hemispheres as the motor disorders increase. Localization of these changes is similar to the topography of the fronto-pontine, parietotemporo-pontine and occipito-mesencephalic motor tracts cortical projections. Conclusions This results demonstrate a greater sensitivity of EEG responses to the degree of motor defect compared with hemodynamic (fMRI). They confirm our hypothesis put forward earlier on the possible participation of the extra-pyramidal system in compensating for the post-traumatic motor defect. Supported by RFFI 18-013-00355 .