Psychophysiologische und psychoneuroimmunologische Ergebnisse zur Neurodermitis Übersicht und kritische Bilanz

Results of psychophysiological, psycho-endocrinological,and psychoneuroimmuno-logical research on the skin in patients with atopic dermatitis were evaluated. 11 investigations were selected and analysed with respect to both design and results. In 6 instances, healthy or ill control groups were included, rarely did the sample size exceed 30. With respect to physiology, blood pressure, heart rate and EDA were most commonly assessed; with respect to immunology, number of leucocytes and differential bloodcount and with respect to psychology, anxiety, neu-roticism and stress perception.The results involving stress induction, itching induction and the relationship of personality and skin parameters were not consistent.The best established relationship is that between skin reactivity (flare, wheal size and pruritus) on the one hand and cognitive appraisal of stress-stimuli and the experimental situation on the other hand. Psychoendocrinological and even more psychoimmunological indicators of the stress of reaction - unlike psychophysiological indicators - were correlated with the skin response. Only half of the studies found an elevated physiological stress reaction in patients with atopic dermatitis.