Effect of hypoxemia on erythropoietic activity of organs during perfusion

The effect of hypoxemia in vivo for 45 min on erythropoietic activity of the kidney, liver, spleen, and sternum was investigated by the method of normoxic perfusion of isolated organs. An increase in erythropoietic activity was found after perfusion of the liver for 6 h, confirming that this organ participates in the extrarenal excretion of erythropoietic factor.