ВЛИЯНИЕ КОМПЛЕКСНОГО СРЕДСТВА «ТИРЕОТОН» НА СВОБОДНОРАДИКАЛЬНЫЕ И ЭНЕРГЕТИЧЕСКИЕ ПРОЦЕССЫ В МОЗГЕ КРЫС ПРИ ГИПОКСИИ/РЕОКСИГЕНАЦИИ

Hypoxia, as universal pathological process accompanying or determining the development of various pathological conditions, activates lipid peroxidation followed by disturbance of cell energy-producing system. The paper deals with the influence of phytoremedy «Tireoton» on free radical processes and energy metabolism in the brain of rats subjected to hypobaric hypoxia/reoxygenation. Experiments were conducted on 44 Wistar rats. It has been found that «Tireoton» at the dose of 50 mg/kg increases catalase activity and the content of reduced glutathione on the average by 20% as well as decreases the content of TBA-active products in 1,5 times in rat brain against the background of acute hypobaric hypoxia. «Tireoton» administration improves cell energy status at the early post-hypoxia period: a 2,8-fold increase in ATP content and 1,5-fold decrease in lactate/pyruvate ratio compared to the control animals were noted. The results obtained permit «Tireoton» to be considered as promising herbal remedy to correct free radical and energetic processes in the brain under hypoxia/reoxygenation.