CLINICAL PATHOLOGICAL FEATURES OF CANINE HEMATOPOIETIC NEOPLASMS ASSESSED VIA FLOW CYTOMETRY

3 1INTRODUCTION 4 2FLOW CYTOMETRY 5 2.1Technical aspects 5 2.2Applications in companion animals oncology 10 3AIM OF THE STUDY 23 4MATERIALS AND METHODS 26 4.1Canine large B-cell lymphoma staging 27 4.2Phenotypic aberrancies in canine lymphomas 31 4.3Expression of CD44 in blood from dogs with hematopoietic neoplasms 33 5RESULTS 35 5.1Canine large B-cell lymphoma staging 35 5.2Phenotypic aberrancies in canine lymphomas 46 5.3Expression of CD44 in blood from dogs with hematopoietic neoplasms 52 6DISCUSSION 54 7CONCLUSIONS 75 8REFERENCES 76 9APPENDIX 91