Botryllamide G is an ABCG2 inhibitor that improves lapatinib delivery in mouse brain

Jonathan D. Strope,Cody J. Peer,Tristan M. Sissung,O. Morgan Hall,Phoebe A. Huang,Emily M. Harris,Kirk R. Gustafson,Curtis J. Henrich,Dina M. Sigano,Gary T. Pauly,Joel P. Schneider,Susan E. Bates,William D. Figg

Botryllamide G is an ABCG2 inhibitor that improves lapatinib delivery in mouse brain

2019

Jonathan D. Strope
Cody J. Peer
Tristan M. Sissung
O. Morgan Hall
Phoebe A. Huang
Emily M. Harris
Kirk R. Gustafson
Curtis J. Henrich
Dina M. Sigano
Gary T. Pauly
Joel P. Schneider
Susan E. Bates
William D. Figg

ABSTRACTIntroduction: Transporters comprising the blood-brain barrier complicate delivery of many therapeutics to the central nervous system. The present study ascertained whether the natural produ...

Keywords:

Transporter
Central nervous system
Biology
Abcg2
Cancer research
Botryllamide G
Blood–brain barrier
Lapatinib
Natural product

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