Twice Daily Versus Once Daily Radiation Therapy in Unselected Limited-Stage Small Cell Lung Cancer Patients: “Medicine-Based” Evidence

ipsilateral primary tumor (r Z 0.965, 0.897; p Z 0.008, 0.015). It was significant correlation of displacement of the left group of lymph nodes in LR and the right group in AP with rates of volume change of ipsilateral lung (r Z 0.609, 0.645; p Z 0.035, 0.024). There were significant correlations between displacement of the left group lymph nodes and rates of volume change of heart in LR, AP and SI directions (r Z 0.614, 0.897, 0.607; p Z 0.044, 0.015, 0.037). Conclusions: There was no difference between the displacements of primary lung tumor and the lymph nodes in three directions during free breathing. The displacement of left primary lung tumor was able to predict displacement of left mediastinal lymph nodes of trachea in the LR and AP directions. Meanwhile, it was reasonable to predict three-dimensional lymph node motion by monitoring the rates of volume change of ipsilateral lung and heart for the mediastinal lymph nodes located in 1L, 2L, 4L, and 5 regions. Author Disclosure: S. Wang: None. J.B. Li: None. H.X. Xing: None. Y.J. Zhang: None. T.Y. Fan: None. M. Xu: None. Q. Shao: None. F.X. Li: None.