Synthesis of Enantioenriched 1,2-trans-Diamines Using the Borono-Mannich Reaction with N-Protected α-Amino Aldehydes.

The three-component Petasis borono-Mannich reaction starting with easily accessible N-protected α-amino aldehydes produces efficiently and diastereoselectively 1,2-trans-diamines with an enantiomeric excess of up to 98%.