MB-88QUANTITATIVE PROTEOMIC PROFILING IN MEDULLOBLASTOMA RECAPITULATES SUBGROUPING BASED ON TRANSCRIPTIONAL PROFILES

There is an important need to identify clinically reliable protein markers, which can be used for medulloblastoma subgroups assignment. Using our established proteomics-based target discovery program, we propose to identify and validate protein-based markers that are main pro-oncogenic signaling components in different molecular and clinical subgroups in medulloblastoma.