High Cutoff Membranes for Mediators Removal

Abstract During the last decade, the blood purification therapies have been proposed as effective treatment to control the cytokines dysregulation in systemic inflammatory syndromes. Among them, treatment with high cutoff membranes is characterized by larger pore size and more effective clearance for middle molecular weight molecules (such as cytokines). Clinical and experimental studies show that the use of high effluent flows in a pure diffusive treatment effectively removes serum cytokines with a safe profile in albumin clearance. In clinical studies, the removal of these inflammatory mediators are associated to a significant improvement in hemodynamic condition, oxygenation indices, and organ dysfunction.