The influence of quetiapine and risperidon on seroprolactin in the patients with schizophrenic

Objective To study the influence of quetiapine and risperidon on semprolaetin and the relationship between semprolactin and drug efficiency.body weight and insulin resistance.Method 64 cases with schizophreniac which stopped taking drugs for more than 1 month were given quetiapine(n=31)and risperidon(n=33)respectively.Their fasting seropmlactin,leptin,insulin,blood sugar level,body height and weight were measured before and 8 weeks after treatment.To evaluate body lipid by BMI[BMI=weight/height2(kg/m2)].Insulin resistance was evaluated by insulin resistance index(HOMA-insulin resistance,HOMA-IR=fasting insulin×fasting blood snger)and drug efficiency Was evaluated by BPRS scale.Results Seroprolactin of risperidon group obviously increased after treatment for 8 weeks than before treatment[(487.54±426.04)mlU/L vs(1632.50±1005.31)mlU/L,P=0.000],but seropmlactin of quetiapine group had no obvious changes[before treatment vs after treatment(531.47±420.91)mlU/L vs(478.93±413.18)mlU/L,P=0.687].Regression of multiple factot's showed that seroprolactin was associated with sex and different drugs.Conclusion Risperidon can increase the level of seroprolactin,quetiapine has little effect on seroprolactin.There is no direct correlation among seroprolactin,drug efficiency,weight,leptin and insulin resistance. Key words: Quetiapine; Risperidon; Seroprolactin; Weight; Insulin resistance; Leptin