Applicability of a sucrose solution as a model fluid for single needle dialysis

We aimed to develop an experimental model for single needle dialysis (SND), allowing real-time measurement of both flows and pressures to establish optimal operating conditions for SND. Here, a sucrose solution was applied as a model fluid and compared with bovine blood. The measured flow waveforms as well as pressures were similar for both the model fluid and bovine blood, including a functional recirculation in the venous phase. It is thus suggested that a sucrose solution can be used as a model fluid to establish optimal operating conditions for SND. I. INTRODUCTION In a conventional hemodialysis (HD), blood is removed from and returned to a patient through double puncture needles, respectively. In contrast, SND is a treatment that uses sigle puncture needle with a Y connector to take out blood from a patient (arterial phase) and return it to the patient (venous phase) after purification. Thus, these two flow phases alternate continually during treatment. However, there have been no detailed investigations on optimal operating conditions of SND. Here, we evaluated the applicability of a sucrose solution as a model fluid and compared it with bovine blood.