Effects of the Pharmacological Pre-treatment and Global Brain Ischemia on the Body Temperature in Experimental Rats

The aim of this study is to examine the influence of the pharmacologic pre-treatment and global brain ischemia on the one hand, and on the other hand, the influence of anaesthesia on the body temperature in experimental rats. The study involves 48 white female experimental rats (n=48), strain - Wistar, with body weight ranging from 230 g to 390 g, and age range of 3-5 months. The rats were divided into two groups. All of the rats were anesthetised and underwent various pharmacologic pre-treatments (with erythromycin and physiologic solution) and global brain ischemia with a reperfusion period. The obtained results demonstrate increased body temperature during the anaesthesia, a decrease during ischemia in both groups, and also a significant increase of the temperature 18 hours after the induced global brain ischemia. However, no significant temperature differences were registered between the groups. It can be concluded that the pre-treatment with a single dose of the macrolide antibiotic erythromycin does not cause any significant variations of the body temperature in experimental rats, and this under conditions of anaesthesia and global brain ischemia.