Phosphorylation by mTORC1 stablizes Skp2 and regulates its oncogenic function in gastric cancer

Qirong Geng,Jianjun Liu,Zhaohui Gong,Shangxiang Chen,Shuai Chen,Xiaoxing Li,Yue Lu,Xiaofeng Zhu,Hui Kuan Lin,Dazhi Xu

Phosphorylation by mTORC1 stablizes Skp2 and regulates its oncogenic function in gastric cancer

2017

Qirong Geng
Jianjun Liu
Zhaohui Gong
Shangxiang Chen
Shuai Chen
Xiaoxing Li
Yue Lu
Xiaofeng Zhu
Hui Kuan Lin
Dazhi Xu

Background Both mTOR and Skp2 play critical roles in gastric cancer (GC) tumorigenesis. However, potential mechanisms for the association between these two proteins remains unidentified.

Keywords:

Biology
PI3K/AKT/mTOR pathway
Cancer
Cancer research
SKP2
Phosphorylation
Carcinogenesis
mTORC1

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