Study of the dependence of the permeability of phosphatidylcholine liposomes for glucose on their prostaglandin level

: It was found that incorporation into phosphatidylcholine monolamellar liposomes of prostaglandin E1 or its synthetic analog containing a phenol group instead of a carboxyl one leads to a significant decrease of the liposome permeability for glucose. The prostaglandin E1 analog appeared to be more membrane-active one. The data obtained were compared with the experimentally established changes in the monolayer compressibility. The experimental results are discussed in terms of a theoretical model which entails that this permeability is proportional to the number of dynamic whose diameter markedly exceeds the molecular size of glucose.