Personal experiences with Minitrol

: Minitrol (.5 mg megestrol acetate) is an oral contraceptive preparation whose effect is directed toward a lower level than hypothalamic-hypophysial-ovarian preparations, and it does not affect the neurohormonal regulation of the cycle. 28 women participated in the experiment, taking Minitrol for 1-8 months. 122 cycles were examined. Acne and increased hair loss were experienced, believed to be due to relatively strong antiestrogen effects of the preparation. Of the 122 cycles, 68% fluctuated between 26-32 days, 6% were longer and 26% shorter. In 10% of the cases, intermenstrual bleeding occurred. In 1 woman whose cycle was irregular, an endometrial polyp was found. For a certain number of women, the .5 mg dosage is too strong, and its effect exceeds the desired contraceptive level as well as disturbs ovarian activity. For the group of women for which the preparation is too strong, a capsule with lesser content is recommended, as this contraceptive substance is highly suitable to young women.