Widespread genomic breaks generated by activation-induced cytidine deaminase are prevented by homologous recombination

Muneer G. Hasham,Nina M Donghia,Eliot Coffey,Jane Maynard,Kathy J. Snow,Jacquelyn Ames,Robert Y Wilpan,Yishu He,Benjamin L. King,Kevin D. Mills

Widespread genomic breaks generated by activation-induced cytidine deaminase are prevented by homologous recombination

2010

Muneer G. Hasham
Nina M Donghia
Eliot Coffey
Jane Maynard
Kathy J. Snow
Jacquelyn Ames
Robert Y Wilpan
Yishu He
Benjamin L. King
Kevin D. Mills

Activation-induced cytidine deaminase triggers somatic hypermutation and immunoglobulin class switching. Mills and colleagues show that it can also cause widespread mutations outside the immunoglobulin heavy-chain locus.

Keywords:

Somatic hypermutation
Homologous recombination
Genome instability
DNA-binding protein
Activation-induced (cytidine) deaminase
Biology
Antibody
Cytidine deaminase
Immunoglobulin class switching
Molecular biology
Genetics

Correction
Source
Cite
Save
Machine Reading By IdeaReader

References

Citations