THE FEATURES OF LIPID METABOLISM IN RATS UNDER THE CONDITIONS OF BISPHENOL A ADMINISTRATION AND LOW-LEVEL LASER IRRADIATION

Problem. Chronic exposure to bisphenol A (BPA), a compound widely used as a component of household polycarbonate products, induces the development of pathologies associated with metabolic disorders. Low-intensity laser irradiation (LLLI) has become widely used for both therapeutic and corrective purposes. However, its efficacy and the mechanism underlying the corrective effect of laser in various pathological conditions, including metabolic syndrome, depend on a wide range of parameters of laser and target tissues and therefore requires diverse research.The aim of the study was to investigate the features of lipid metabolism in rats under the conditions of BPA and low-level laser irradiation.Methods. ВРА was administered per os daily for 3 days at a dose of 50 mg/kg body weight. Irradiation was performed for 2 min with a low-diode laser λ = 650 nm (50 mW, 1.5 J/cm2 and 12.5 mW/cm2).Results. It was shown that the administration of BPA was accompanied by the development of dyslipidemia, which was expressed in an increase in triacylglycerols, total cholesterol, LDL and VLDL levels in the serum of animals. The obtained results   may be related to the accumulation of lipids in the liver under the conditions of xenobiotic administration, which is confirmed in our studies by an increase in the levels of total cholesterol, triacylglycerols and fatty acids in the liver of bisphenol A-exposed animals. Changes in the lipid profile of blood serum and lipid content in the liver may be the result of hepatotoxic effects of bisphenol A.At the same time, irradiation of animals with a low-level diode laser, after the administration of BPA, led to a decrease in total cholesterol, triacylglycerols in both serum and liver tissue, which is associated with inhibition of SREBP and reduced activity of enzymes that play a key role in lipogenesis and lipolysis processes.Conclusions. The administration of bisphenol A is accompanied by lipid metabolism disorders, while low-level laser irradiation of animals corrects the obesogenic effect of the studied xenobiotic.Keywords: bisphenol A, low-intensity laser irradiation, obesogen, hypercholesterolemia, triacylglycerolemia