Glucose-Mediated Insulin Release Carrier

Polyacrylic acid-co-methacrylamidophenylboronic acid) (PAA-co-PMAAPBA) copolymers were prepared using different concentrations of 3-methacrylamidophenylboronic acid (MAAPBA). The release of insulin from the insulin loaded polymer is dependent on the composition between acrylic acid and MAAPBA in the copolymer. With an increase in concentration of 3-methacrylamidophenylboronic acid, the glucose responsive insulin release from polyacrylic acid-co-methacrylamidophenylboronic acid) polymer at the physiological pH of 7.4 was enhanced. The presence of glucose resulted in disintegration of the polymer leading to release of the loaded insulin.