Synthesis, antiamoebic and molecular docking studies of furan-thiazolidinone hybrids.

Abstract In continuation of our previous work, a series of furan-thiazolidinone hybrids was prepared by Knoevenagel condensation of 3-(furan-2-ylmethyl)-2-(phenylimino)-1, 3-thiazolidin-4-one with different aryl aldehydes in presence of strong base. Some members of the series exhibited remarkable antiamoebic activity and cell viability. Three compounds (3 , 6 and 11) showed excellent binding energy for Entamoeba histolytica O -acetyle- l -serine sulfohydrolase and Entamoeba histolytica thioredoxin reductase. These compounds demonstrated significant inhibition of O -acetyle- l -serine sulfohydrolase. The promising antiamoebic activity and enzymatic assay of 3 , 6 and 11 make them promising molecules for further lead optimization in the development of novel antiamoebic agents.