MicroRNA-30c inhibits human breast tumour chemotherapy resistance by regulating TWF1 and IL-11.

Jessica Bockhorn,Rachel Dalton,Chika Nwachukwu,Simo Huang,Aleix Prat,Kathy Yee,Ya-Fang Chang,Dezheng Huo,Yujia Wen,Kaitlin E. Swanson,Tyler Qiu,Jun Lu,Seo Young Park,M. Eileen Dolan,Charles M. Perou,Olufunmilayo I. Olopade,Michael F. Clarke,Geoffrey L. Greene,Huiping Liu

MicroRNA-30c inhibits human breast tumour chemotherapy resistance by regulating TWF1 and IL-11.

2013

Jessica Bockhorn
Rachel Dalton
Chika Nwachukwu
Simo Huang
Aleix Prat
Kathy Yee
Ya-Fang Chang
Dezheng Huo
Yujia Wen
Kaitlin E. Swanson
Tyler Qiu
Jun Lu
Seo Young Park
M. Eileen Dolan
Charles M. Perou
Olufunmilayo I. Olopade
Michael F. Clarke
Geoffrey L. Greene
Huiping Liu

The role of microRNAs in chemotherapy resistance remains to be elucidated. Bockhorn et al. report that microRNA-30c, a human breast tumour prognostic marker, has a key role by targeting the epithelial-to-mesenchymal transition promoter twinfilin 1 and downstream interleukin-11 expression.

Keywords:

Gene expression profiling
Microfilament Protein
microRNA
Doxorubicin
Cytoskeleton
Epithelial–mesenchymal transition
Molecular biology
Real-time polymerase chain reaction
Cancer research
Interleukin 11
Biology
chemotherapy resistance
human breast

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