The distribution of complexes 69mZnL1Cl2, [69mZn(L2)2]Cl2, and [69mZn(L2)2]Sal2 (L1 is N-(5,6-dihydro-4H-1,3-thiazin-2-yl)benzamide, L2 is 2-aminopyrimidine, Sal is a salicylate ion) in vivo in mice

The distribution of complexes of thiazine and pyrimidine derivatives possessing antileukemic activity and labeled with radionuclide 69mZn in the organs of mice and its rate of excretion were studied. A solution of ZnCl2 was used for comparison. An increase in the time of excretion of the drug from the body and a decrease of its penetration into the brain in the presence of a salicylate ion were observed.