Network homogeneity reveals decreased integrity of default-mode network in ADHD
2008
Abstract Examination of spontaneous intrinsic brain activity is drawing increasing interest, thus methods for such analyses are rapidly evolving. Here we describe a novel measure, “network homogeneity”, that allows for assessment of cohesiveness within a specified functional network, and apply it to resting-state fMRI data from adult ADHD and control participants. We examined the default mode network, a medial-wall based network characterized by high baseline activity that decreases during attention-demanding cognitive tasks. We found reduced network homogeneity within the default mode network in ADHD subjects compared to age-matched controls, particularly between the precuneus and other default mode network regions. This confirms previously published results using seed-based functional connectivity measures, and provides further evidence that altered precuneus connectivity is involved in the neuropathology of ADHD. Network homogeneity provides a potential alternative method for assessing functional connectivity of specific large-scale networks in clinical populations.
Keywords:
- Molecular biology
- Precuneus
- Brain activity and meditation
- Resting state fMRI
- Social psychology
- Homogeneity (statistics)
- Elementary cognitive task
- Default mode network
- Attention deficit hyperactivity disorder
- Posterior cingulate
- Artificial intelligence
- Pattern recognition
- Psychology
- Group cohesiveness
- functional connectivity
- Neuroscience
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