Stereoselective synthesis of stable isotopomers of meso -2,6-diaminopimelic acid

References [1] M. J. Pucci et al., Clin. Microbiol. Rev. 2013, 26, 792-821. [2] M. S. Butler et al., J. Antibiot. 2013, 66, 571-591. [3] A. Zervosen et al., Molecules 2012, 17, 12478-17505. Figure 4 | 13C-Allylglycine synthesis. i) Cbz-Cl, NaOH (aq), toluene, 0 °C  rt ; tBuOH, DCC, DMAP, CH2Cl2 ; H2 (6 bar), Pd/C (10%wt, dry), HCl, MeOH ; Ph2C=NH, CH2Cl2, MgSO4. ii) CH2=CH-CH2-Br, KOH (50%wt, aq), toluene, CH2Cl2, -20 °C. iii) citric acid (10%wt, aq), THF ; Fmoc-OSu, THF, H2O (51%, 7 steps).