Development of a spray-type adhesion barrier

We developed a novel spray-type dextrin hydrogel-based adhesion barrier designed to create a site-specific barrier on a target. Our novel hydrogel is composed of Powder A, which mainly contains N-hydroxysuccinimide-modified carboxymethyl dextrin and trehalose as a stabilizing agent, and Powder B, which is composed of sodium carbonate and sodium hydrogen carbonate. Here, we describe the product specifications of the hydrogel and results of in vivo performance evaluations and clinical studies to demonstrate its efficacy and safety. A novel spray-type dextrin hydrogel-based adhesion barrier is composed of N-hydroxysuccinimide-modified carboxymethyl dextrin that is biodegradable polymer material. The performance evaluation of a spray-type adhesion barrier in porcine laparoscopic model was showed significantly lowered adhesion rate than in the control group (p < 0.001), and no hydrogel residue was observed macroscopically at the spraying site 28 ± 1 days after surgery.