Застосування L-аргініну в комплексному лікуванні хворих на артеріальну гіпертензію з цукровим діабетом в перименопаузі

The aim of research was comparing the influence of basic therapy (lisinopril or amlodipine) as a monotherapy and its combination with nitrogen oxide donator – L-arginin in the patients with arterial hypertension in perimenopause with comorbid diabetes mellitus and without it. Material and methods of our investigation: we examined 104 patients using biochemical (endothelin’s level determination) and instrumental (Doppler echocardiography) diagnostic methods. Result. Results have shown that on the background of treatment, myocardial function improves and diastolic dysfunction is regressing in all patient’s groups. The most pronounced changes we can see in the subgroup of the patients, who additionally used L-arginine. The endothelin’s-1 level changes are also the most pronounced in patients, who used L-arginine. The feasibility of L-arginine adding is justified as it has positive influence on the endothelial dysfunction, which manifested itself in a decreased endothelin’s-1 level. Conclusions. We have shown that on the background of treatment the myocardial contractility become better. The most pronounced changes we can see in the subgroup of the patients, who used L-arginine (diastolic dysfunction regressed from the second to the first type in 21 patients (47.7 %), which prove a positive influence on the left ventricular filling pressures)