The Effect of Aerobic Exercise on Atheromatous Plaques Area and inflammatory-ralated Serum Cytokines of ApoE-Deficient Mice

Objective: ApoE-deficient mice was used as AS model to approach the effect and mechanism of aerobic exercise on formation of atherosclerotic lesions and the effect of serum inflammatory-related cytokines.Method: ApoE-deficient mice were randomly divided into control group(CG) and exercise group(EG,swimming,90min/d,6d/w,10 wks),the lesion area and serum lipid and serum inflammatory-related cytokines were tested after 10 weeks.Result: 1) Compared with CG,the lesion area in the aorta of EG was significantly less than that of the CG(P0.05).And the serum lipid was improved significantly.2) Compared with CG,the serum levels of TNF-α and IL-6 were significantly down-regulated in the EG(P0.01),and the adiponectin level was up-regulated significantly(P0.01).Conclusion:1) The results suggested that aerobic exercise significantly decreased the development of atherosclerotic plaque in apoE-deficient mice and simultaneously improved the fat metabolism.2) Aerobic exercise significantly decreased the pro-inflammatory cytokine and increased the anti-inflammatory cytokine simultaneously in apoE-deficient mice.The systemic inflammation can be effectively improved from aerobic exercise.