Thermal hazard assessment of the thermal stability of acne cosmeceutical therapy using advanced calorimetry technology

Abstract In recent years, a number of cosmeceutical incidents have occurred both domestically and internationally. These incidents range from minor burns on the skin to the explosion of a cosmeceutical factory. In most of these incidents, benzoyl peroxide (BPO) was reported as one of the hazardous compounds involved. Even after dilution, BPO still poses a hazard. This study examined the thermal stability parameters of BPO by using differential scanning calorimetry, thermogravimetric analyzer, and thermal activity monitor III. Advanced thermokinetic models were integrated and calculated, and complete thermal stability analysis of low concentration of BPO was conducted. The findings of this study may be used as a reference in future research on BPO decomposition.