Layer-by-layered construction of oxygen-generating photo-responsive nanomedicine for enhanced photothermal and photodynamic combination therapy

A multifunctional photosensitive and photothermal nanomedicine, AMP-Ce6-HA, was prepared by sequencially layering hard and soft functional molecules. AMP-Ce6-HA was efficiently picked up by MDA-MB-231 breast cancer cells, and then released oxygen in lysosomes. The photothermal and oxygen-enhanced photodynamic combination ttherapy was much more effective than the single ones.