Freeze drying nanoparticulate systems

Particulate systems are various size, shapes and morphologies (nano- microparticles, liposomes, core-shell..). The development of these particulate systems is becoming increasingly important as a result of diverse industrial applications. The poor stability in aqueous medium of these systems constitutes a real obstacle to their commercialization. In this context, freeze drying is considered as the most convenient process to improve their long term stability. In this presentation, one will discuss the most important parameters that influence the success of freeze-drying of particulate systems and provides an overview of freeze-drying process and formulation strategies with a focus on the impact of formulation and process on particle stability.