Squalene epoxidase promotes the proliferation and metastasis of lung squamous cell carcinoma cells though extracellular signal-regulated kinase signaling: SQLE promotes malignancy of lung SCC

Background The biological function of squalene epoxidase (SQLE), an important rate‐limiting enzyme in downstream cholesterol synthesis, is to convert squalene to 2‐3 oxacin squalene. The expression of SQLE in lung cancer is abnormal. We conducted this study to investigate the effect of SQLE expression on lung squamous cell carcinoma (SCC) proliferation, migration, and invasion and its role in extracellular signal‐regulated kinase (ERK) signaling.