Biodistribution and Pharmacokinetics of Dapivirine-Loaded Nanoparticles after Vaginal Delivery in Mice

José Neves,Francisca Araújo,Fernanda Andrade,Mansoor Amiji,Maria Fernanda Bahia,Bruno Sarmento

Biodistribution and Pharmacokinetics of Dapivirine-Loaded Nanoparticles after Vaginal Delivery in Mice

2014

José Neves
Francisca Araújo
Fernanda Andrade
Mansoor Amiji
Maria Fernanda Bahia
Bruno Sarmento

Purpose To assess the potential of polymeric nanoparticles (NPs) to affect the genital distribution and local and systemic pharmacokinetics (PK) of the anti-HIV microbicide drug candidate dapivirine after vaginal delivery.

Keywords:

Microbicides for sexually transmitted diseases
Vaginal delivery
Dapivirine
Microbicide
Pharmacology
Biodistribution
Pharmacokinetics
Chemistry
drug candidate
polymeric nanoparticles

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