112 – METAL ION LEVELS IN PATIENTS WITH LARGE HEAD METAL-ON-METAL TOTAL HIP PROSTHESIS

Purpose: Several studies have shown elevated levels of metal ions in blood of patients with metal-on-metal (MM) total hip arthroplasty (THA). To minimize wear, the elastohydrodynamic theory suggests wear reduction for larger diameter head bearings. This significant reduction in wear has been demonstrated in hip simulators for the 36 mm-head compared to the 28 mm-head prosthesis. However, the survival of larger head MM THAs and the levels of metal ions in the blood of patients having these implants are still to be determined. Method: Fifty (50) patients (56 hips) who received a DePuy Ultamet™ MM hip bearing (40/44 mm-head) at our Institution between July 1st 2007 and August 31st 2008 were included in the study. Clinical and radiologic data were collected pre-operatively as well as at 6–8 weeks, 4–6 months, and 1 year postoperatively. Results were compared to those of subjects (65 patients, 71 hips) who received a 36 mm-head prosthesis. Cobalt (Co) and chromium (Cr) concentrations were measured at 1 year post-operatively in the blood of patients by ICP-MS. Since Co and Cr ions have the potential to induce irreversible biochemical damage to macromolecules, the levels of oxidative stress markers (total antioxidants and lipid peroxides) were measured in the plasma of these patients. Results: At their 1-year post-operatively follow-ups, all patients were doing well and no sign of osteolysis was observed on X-rays. Harris Hip Score increased in both groups with a tendency to higher score in the 40–44 mm group compared to the 36 mm group. Activity score also increased in both groups after 1 year without statistical significant differences. Results also show that the levels of Co and Cr ions increased significantly in both groups compared to the Pre-OP control group. The levels of Co were also significantly higher in patients with large head arthroplasty (40 and 44 mm-head) compared to those of the 36 mm-head group (p=0.012). The levels of Cr were similar in both the large head and the 36 mm-head group (p=0.41). Finally, results show that there were no differences in the levels of total antioxidants and peroxides between the 40–44 mm group and the 36 mm group. Moreover, there was no increase in the level of these markers of oxidative stress compared to the Pre-OP control group. Conclusion: The present study shows that at 1-year postoperatively, patients with large 40–44 mm-head THA had comparable clinical outcomes than those with 36 mm-head prosthesis. However, the levels of Co ions were significantly higher in these patients compared to patients with 36 mm-head THA. This suggests a higher health risk for these patients due to the presence of these ions. However, there were no effects on the levels of oxidative stress markers in the blood of these patients, suggesting that there is no increased risk at short-term. In conclusion, due to the high level of Co ions, longer follow-ups are required to conclusively determine the outcomes of the patients and the survivorship of these new bearings.