Mixed inhibitors of n-aminopeptidase and neprilysin

Mixed inhibitors of aminopeptidase N and neprilysin are described. Pharmaceutical compositions containing at least one of these compounds, used alone or in combination with morphine and its derivatives, endocannabinoids and inhibitors of their metabolism, GABA derivatives such as gabapentin or pregabalin, duloxetine or methadone, can be used as an analgesic, anxiolytic, antidepressant or anti-inflammatory.