Recent advance in endoplasmic reticulum stress-mediated inflammatory response after intracerebral hemorrhage

Endoplasmic reticulum (ER) stress is an important mediator causing inflammatory response, which additionally exerts secondary injury after intracerebral hemorrhage (ICH) to influence brain function recovery through a variety of cell signaling and response, to regulate neural cells survival or death. Therefore, further understanding about the relation between ER stress and inflammatory response as well as the signal transduction pathway can provide new therapeutic strategies and evidence for treatment of ICH. The present review summarizes the process of ER stress activation and the relation between inflammatory response and ER stress activation after ICH. Key words: Intracerebral hemorrhage; Inflammatory response; Endoplasmic reticulum stress; Unfolded protein response