Прогностическая роль генетических маркеров в формировании особенностей течения пневмокониозов в постконтактном периоде

Based on studies of certain gene-candidate polymorphism, the authors studied markers of early development and unfavorable course of pneumoconiosis in post-contact period. Analysis covered occurrence of genotypes and allels of I/D polymorphism of gene CCR5, 4a/b polymorphism of gene NOS3, VNTR polymorphism of gene IL1RN, I/D polymorphism of CASP8 and mutation GLU342LYS (rs28929474) and GLU264VAL (rs17580) in gene SERPINA1 in patients with various terms of pneumoconiosis formation. Findings are individual criteria of early formation and progress of pneumoconiosis in post-contact period.