Animal experiment of pediatric Luo-Ye pneumonic ventricular assist device

Objective To evaluate the pediatric Luo-Ye pneumonic ventricular assist device (Luo-Ye pump) as a left ventricular assist device in the goat.Methods Fourteen goats weighing ( 14.8 ±1.4) kg were randomly individed into Luo-Ye pump group ( L-Y group,n = 7 ) and Berlin heart Excor group (BH group,n =7).Proximal descending aorta and left atrium were cannulated with Fl4 aortic cannula and F22 venous cannula respectively,and then cauunlas were connected with the pumps which were controlled by Medos drive unit.The mean blood pressure,heart rate and driving data were recorded during experiment.The serum platelet granulate membrane protein,free hemoglobin,hepatic and renal functions were assayed.Results The positive pressure of drive unit in L-Y group was less than that in BH group ( 103 ±4) mm Hg vs ( 165 ± 22) mm Hg,P＜O.05.The flow rate in L-Y group was higher than in BH group ( 1.20 ±0.20) L/min vs (0.94 ±0.22) L/min,P ＜0.05.The mean blood pressure and heart rate had no signiftcant changes during the experiment in two groups.There was no significant difference between two groups in the serum levels of platelet granulate membrane protein and free hemoglobin.No significant difference was found in the hepatic and renal functions between two groups.Conclusion The Luo-Ye pump demonstrated good initial hemodynamic performance and less injury to the blood,hepatic and renal function as Berlin heart Excor did.Furthermore,the driving date of Luo-Ye pump was better than that of Berlin heart Excor. Key words: Pneumatic ventricular assist device;  Children Luo-Ye pump;  Animal experiment