Replication inhibitors of human immunodeficiency virus

2008 
A compound of formula (I) and an isomer, racemate, enantiomer or diastereomer thereof: Formula ** ** wherein ------- represents a single bond or a double bond; X is N when Y is N-R7; or X is N-R6 when Y is N; R2 and R5 each independently a) halo selected; b) R8, -C (> = O) -R8, -C (> = O) -O-R8, -O-R8, -S-R8, -SO-R8, -SO2-R8, -C (C1 - 6) -R8, -alkylene (C1 - 6) -C (> = O) - R8, -C (C1 - 6) -C (> = O) -O-R8, -C (C1 - 6) - O-R8, -C (C1 - 6) -S-R8, -C (C1 - 6) -SO-R8 or - (C1 - 6) -SO2-R8; wherein R8 is selected in each case independently H, alkyl (C1 - 6), alkenyl (C2 - 6), alkynyl (C2 - 6), (C1 - 6), cycloalkyl (C3 - 7), aryl and Het; and wherein each of the aryl and Het is optionally substituted with 1 to 3 substituents each selected independently from: i) halo, oxo, thioxo, (C2 - 6), (C1 - 6), cycloalkyl ( C3 - 7), cycloalkyl (C3 - 7) cycloalkyl- (C1 - 6) -, -OH, -O-alkyl (C1 - 6), O-halo (C1 - 6), -SH, -S-alkyl ( C1 - 6), -SO (C1 - 6), -SO2- (C1 - 6), -NH2, -NH (C1 - 6) and -N (((C1 - 6) 2; ii) (C1 - 6) alkyl optionally substituted with -OH, -O- (C1 - 6) or -O-alkyl (C1 - 6); and iii) aryl or Het, wherein each of the aryl and Het is optionally substituted with halo or (C1 - 6); c) -N (R9) R10, -C (> = O) -N (R9) R10, -OC (> = O) -N (R9) R10, -SO2-N (R9) R10, -C (C1 - 6) -N (R9) R10, -C (C1 - 6) -C (> = O) -N (R9) R10, -C (C1 - 6) -OC (> = O) -N (R9) R10 or -C (C1 - 6) -SO2-N (R9) R10 where R9 is selected in each case independently H, (C1 - 6) and cycloalkyl (C3 - 7); and R10 is selected in each case independently of R8, -C (C1 - 6) -R8, -SO2-R8, -C (> = O) -R8, - C (> = O) OR8 and -C ( > = O) N (R9) R8; wherein R3 and R9 are as defined above.
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