Transplacental carcinogenic action of p-hydroxyphenyllactic acid

Through the transplacental action of the tyrosine metabolite p-hydroxyphenyllactic acid, which has carcinogenic activity, on progeny of CC57BR and C57BL mice, malignant and benign neoplasms (leukemias, lymphosarcomas, adenomas and carcinomas of the lung, hepatomas, papillomas, carcinomas of the bladder, and other tumors) developed in 88 and 78% of cases respectively. The number of these neoplasms was significantly higher than in the control, they appeared sooner, and they were more malignant in character.