O186 Nucleosome Assembly Protein 1-Like 1 Knockdown Promotes Cardiomyocytes Differentiation By Notch Signaling In Mouse Induced Pluripotent Stem Cells

miR-199b overexpression. Futhermore, we found that the effect of Jagged-1 on iPS cell-EC differentiation can be contract by miR-199b inhibitor. meanwhile, we also found that miR199b can regulate the ips differentiation into ECs through VEGF signalling pathway. Conclusion: we conclude that miR-199b plays a critical role in the determination of EC fate during iPS cell–EC differentiation by target JAG-1, which may indicate that miR-199b has a role to promote EC differentiation. Disclosure of Interest: None Declared