The long-term effect of perphenazine enanthate on the rat brain. Some metabolic and anatomical observations.

Perphenazine enanthate 3.4 mg/kg per injection, was administered subcutaneously to rats every second week over a period of a year, a total of 31 mg per animal being given. The animals were observed weekly and only a few became cataleptic during brief periods. After treatment for one year, 3H-uridine and 3H-lysine were administered intravenously and the labelling was studied by micro-autoradiography. Labelling of the cortical cells in the treated animals was found to be slightly greater than in the control animals. The converse was found in the basal ganglia in the case of uridine. None of these differences were significant.