Uptake ofchloroquine andhydroxychloroquine
1987
inunfractionated mononuclear cells andinpurified monocytes,lymphocytes, andneutrophil polymorphonuclear leucocytes (PMN)was measured invitro. Accumulation ofbothdrugsinleucocytes was timeand dosedependent. Cellular levels comparable tothosefoundduring antirheumatic therapy were achieved bypreincubation for60minutes with up to01mM chloroquine orhydroxychloroquine.
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