Uptake ofchloroquine andhydroxychloroquine

inunfractionated mononuclear cells andinpurified monocytes,lymphocytes, andneutrophil polymorphonuclear leucocytes (PMN)was measured invitro. Accumulation ofbothdrugsinleucocytes was timeand dosedependent. Cellular levels comparable tothosefoundduring antirheumatic therapy were achieved bypreincubation for60minutes with up to01mM chloroquine orhydroxychloroquine.