METHODOLOGy OF MEMORy STUDy IN PHARMACOLOGICAL CORRECTION OF ITS DISORDERS IN ALCOHOLICS SUFFERED FROM TRAUMATIC bRAIN INjURy

The main goal of the current research was to assess memory impairments via learning curves and its restoration during the process of rehabilitative treatment of alcoholic patients having traumatic brain injury with pharmacological correction. We applied a mathematical model Y = B3*exp(-B2*(X-1))+B4*(1-exp(-B2*(X-1))), where X is the trial number; Y is the number of recalled correct words, B2 is the learning rate, B3 is readiness to learn and B4 is ability to learn. Readiness to learn and ability to learn were significantly below in alcoholic patients in comparison with healthy participants. Treatment with vasorelaxants Cinnarizine and Dibazol, central muscle relaxant Baclofen, nootropics Nootropil and Aethimizol, as well as actoprotector Metaprot (Bemithyl) returned readiness to learn up (shortterm memory) to normal values. However, ability to learn (long-term memory) was restored only with Dibazol. Use of 10 words in a list of Luria's memory test is insufficient for exact assessment of the long-term memory and should be increased up to 16 words.