Improvement In Lipid Profile And Thyroid Hormone Profile In Hyperlipidemic Rats By Edible Macrofungi Dacryopinax spathularia AND Schizophyllum commune

The present study was aimed for the assessment of efficacy of aqueous extract of edible macrofungi Dacryopinax spathularia (Schwein) and Schizophyllum commune (Fries) in improvement of lipid profile in two groups of hyperlipidemic rats; one with high fat diet (HFD) and other with induced hypothyroidism. The efficacy of the two macrofungal extracts was also assessed in improvement of thyroid hormone profile in hypothyroidism induced rats. The results revealed the rats with HFD developed hyperlipidemia, in which significant (p=0.01) adverse changes occur in blood levels of lipid profile marker parameters (Total Cholesterol, Triglycerides, LDL and HDL cholesterol). When the hyperlipidemic rats were fed with the two experimental macrofungal extracts, significant (p=0.01) improvement in the Blood levels of these lipid profile marker parameters was observed. The other group of rats developed hyperlipidemia as a result of hypothyroidism induced in them by treatment with 0.1% Aminotriazole. When these rats were fed with the two macrofungal extracts, significant (p=0.05) improvement in parameters of lipid profile was observed. However, on treatment of hypothyroidism induced rats with the macrofungal extracts, slight but significant (p=0.05) increase in T4 level and slight but significant (p=0.05) decrease in TSH level was found. There was no significant change observed in T3 level in blood on treatment with macrofungal extracts. The present work scientifically authenticates the medicinal impact of the tested macrofungal extracts in improvement of lipid profile and thyroid hormone profile, and also reveals the use of the two experimental macrofungi as significant neutraceutical dietary source to prevent hyperlipidemia and thereby the cardio vascular diseases.