Study on pharmacokinetics of brucine from normal and ultra-micro powder of semen strychni in rats

Objective:To study the pharmacokinetic process ofbrucine from normal and ultra-micro powder ofsemen strychni in rat serum.Methods:HPLC techniques were used.All pharmacokinetics parameters were calculated with a 3P87 program.Results:The pharmacokinetics results indicated that the normal powder and the ultra-micro powder ofsemen strychni belonged to two compartment open model.The absorb ofbrucine was just several ten minutes, and there was no obvious difference ofTmax between normal powder and ultra-micro powder.This showed that:Brucine was some material that was easily absorbed.But we can find that Cmax increased from(51.13±0.48)μg/L to(69.26±1.40)μg/L after ultra-micro powder preparation which was quite obvious.K,Ka,B and β had a obvious increase(P0.05) and T1/2β decreased markedly(P0.05).The result showed that both ofthe absorbtion and eliminate had been enhanced after ultra-micro powder preparation and cumulation toxicity can be reduced.Conclusion:The maximum concentration in rat plasma ofbrucine from ultra-micro powder ofsemen strychni was higher than that from normal powder.