Synthesis of some biologically important fluorinated 3-chlorochromones and 1,5-benzothiazepines as antimicrobial and antifungal agents

A series of synthetic 3-chlorochromones and 1,5-benzothiazepines have been synthesized and evaluated for their antimicrobial and antifungal activity against Gram +ve and Gram -ve microorganisms. In these series the chemical transformation of chalcones to respective 3-chlorochromones and 1,5-benzothiazepines by using DMSO/CuCl 2 and 2-aminothiophenol respectively has been carried out. Compounds synthesized have been screened for antibacterial activity using Gentamycin and Cefixime and for antifungal activity using Ketoconazole as reference drugs.